What is the definition of Lubricant and Glidant?
Lubricant is a non-toxic, pharmacologically inactive substance added to the formulation to decrease friction between tablet’s surface and the die wall cavity in which the tablet was formed and to reduce wear and tear of dies and punches. Probably, it is hard to produce a proper tablet without lubricant. Also, various specialist defines the lubricants as below:
Lubricant is a compound added in tablet formulations primarily to reduce friction between the die wall and granules as the tablet is formed and ejected.
A lubricant may be defined as a suitable material, a small amount of which interposed between two rubbings surfaces will decrease friction arising at the interface.
On the other hand, glidant is a non-toxic, pharmacologically inactive substance used to optimize the flow properties of tablet granulation or powder materials by decreasing interparticle friction and cohesion. At a certain range of concentrations, only a glidant may work such as talc 5%. Glidant may inhibit flow properties at above a certain concentration. Moreover, glidant is used in combination with lubricant because they have no ability to reduce die wall friction.
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